Dr. Horton is a Professor of Internal Medicine and Molecular Genetics, Chief of the Division of Digestive and Liver Diseases, and Director of the Center for Human Nutrition who holds the Distinguished Chair in Human Nutrition, the Scott Grundy Director’s Chair, and the Robert C. and Veronica Atkins Chair in Obesity and Diabetes Research at the University of Texas (UT) Southwestern.
He earned his Bachelor of Science and medical degrees from the University of Iowa and completed his internal medicine residency, gastroenterology fellowship, and Howard Hughes post-doctoral fellowship at UT Southwestern. Dr. Horton is a former PEW scholar and A member of the American Society for Clinical Investigation and Association of American Physicians. He serves as a consulting editor forArteriosclerosis, Thrombosis, and Vascular Biology and as an associate editor ofThe Journal of Lipid Research.
In clinical digestive diseases, Dr. Horton has an interest in conditions that lead to fatty liver disease and obesity. Currently, a major focus of the laboratory is to determine how transcriptional regulators of fat metabolism contribute to the development of fatty liver in various disease processes such as diabetes, obesity, and lipodystrophies.
In recent work, Dr. Horton has delineated the function of PCSK9, a protein secreted into the blood that determines plasma cholesterol levels through its action on LDL receptors in the liver.